Institute: The Jenner Institute, Oxford University
Biography
I am Chief Investigator and clinical lead on the blood-stage and transmission blocking malaria vaccine programmes at The Jenner Institute led by Profs Draper and Biswas. This programme of work includes testing of first-time-in-man vaccines against both Plasmodium falciparum and P. vivax malaria, incorporating controlled human malaria infection to test efficacy. I am currently running a Phase IIa study of the protein vaccine RH5.1/AS01B, which incorporates the PfRH5 antigen – the first reported target in the P. falciparum merozoite that is highly susceptible to broadly-neutralising vaccine-induced antibodies.
My main research interest is in human challenge models of infection, having completed a DPhil with Prof Helen McShane at the Jenner Institute in 2009 which involved development of a human challenge model against tuberculosis, using BCG as a surrogate. Prior to this I was lead investigator on several TB vaccine trials, including that of the first candidate prophylactic TB vaccine to have been administered to HIV-infected individuals. I am now working to establish human challenge models for P. vivax malaria in Oxford – this will be the first time that challenge trials with this parasite have been undertaken in Europe.
Key Publications
A list of publications can be found here.
Web Links of Interest