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Dr Brian Roberston

Institute: Imperial College London

 

Biography

The aim of our research is to understand the host-pathogen interactions underlying the complex biology of tuberculosis infection, and to exploit this understanding for development of improved tools for disease control. We use genome-based biology, taking advantage of the availability of mycobacterial sequence data, techniques for mutagenesis and expression profiling, and the natural diversity of clinical isolates. We are investigating different ways to deliver anti-TB drugs, the potential of anti-microbial peptides, and host-directed therapies to improve TB treatment. We are also analysing how mycobacteria grow and divide, using microfluidics-based single cell analysis and time-lapse video microscopy. Analysis and integration of large amounts of data on host and pathogen responses to infection is increasingly dependent on techniques coming from systems biology including image analysis and mathematical modelling.

 

Key Publications

A list of recent publications can be found here.

 

Web Links of Interest

http://www.imperial.ac.uk/people/b.robertson

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