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Dr Patrick Mallia

Dr Patrick Mallia
Senior Clinical Lecturer
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Institute: National Heart and Lung Institute, Imperial College

 

Biography

My research interests are the role of rhinoviruses in COPD and asthma exacerbations. I have developed the first human model of COPD exacerbation using experimental rhinovirus infection in COPD patients, successfully demonstrating that this is a safe and valid model of COPD exacerbation. Using this model we have gained novel insights into mechanisms of virus-induced COPD exacerbations such as impaired antiviral immunity, airway inflammation, oxidative stress, dysregulation of airway glucose and secondary bacterial infections.

 

Key Publications

1) Footitt J, Mallia P, et al. (Joint first author). Oxidative and nitrosative stress and histone deacetylase-2 activity in exacerbations of COPD. Chest 2016;149(1):62-73.

2) Mallia P et al. Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in COPD. American Journal of Respiratory and Critical Care Medicine 2012;186:1117-1124.

3) Mallia P et al.  Experimental rhinovirus infection as a human model of COPD exacerbation. American Journal of Respiratory and Critical Care Medicine 2011;183(6):734-42.

4) Mallia P et al. Lymphocyte subsets in experimental rhinovirus infection in COPD. Respiratory Medicine 2014;108(1):78-85.

5) Mallia P et al. Neutrophil adhesion molecules in experimental rhinovirus infection in COPD. Respiratory Research 2013;14:72.

6) Mallia P et al.  An experimental model of rhinovirus induced COPD exacerbations: a pilot study. Respiratory Research 2006;7:116.

7) Molyneaux PL, Mallia P et al. Outgrowth of the bacterial airway microbiome following rhinovirus exacerbation of COPD. American Journal of Respiratory and Critical Care Medicine 2013; 188 (10):1224-31.

 

Web Links of Interest

https://www.imperial.ac.uk/people/p.mallia

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