Institute: Imperial College London
Biography
In 2009 Trevor Hansel became Medical Director of the Imperial Clinical Respiratory Research Unit (ICRRU) at St Mary's Hospital, having been Medical Director of the NHLI Clinical Studies Unit at the Royal Brompton Hospital from 1997-2009. He is also an Honorary Consultant Immunologist at St. Mary's Hospital in London.
Trevor has a specialist interest in phase II clinical testing of new anti-inflammatory therapies for asthma and COPD, and has worked on a variety of challenge models in patients. In particular, he is working on novel non-invasive methods to sample the airways: using synthetic absorptive matrices to measure cytokines and chemokines in nasal and bronchial mucosal lining fluid. These sampling methods have been developed on nasal allergen challenge, and he is also working on challenges with viruses, cigarette smoke, and agonists for innate immunity (LPS and poly-IC). He also works on human whole blood challenge methods to demonstrate pharmacodynamic activity of anti-inflammatory drugs. Trevor’s research objectives are:
• To further develop novel methods of sampling the airways: by absorption, cell binding and curettage.
• In particular he is currently involved in a NIHR BRC project that develops a series of nasal challenges in man.
• To use these sampling and challenge methods in patients to develop biomarkers, identify novel targets for drugs, and test new anti-inflammatory therapies.
Key Publications
A list of publications can be found here.
Web Links of Interest