Institution:
Department of Medical Microbiology, Radboud University Medical Center
Biography:
I studied medicine and medical biometry. My board certification is in “Tropenmedizin und spezifische Prophylaxe”. The overriding focus of my research is the translation of fundamental research into human studies to improve health: I have been involved in clinical studies of infectious diseases since 1993, with a strong interest in the development of vaccines and new drugs. Though my work has included helminth infections, Ebola, tuberculosis, and SARS-CoV-2, my main interest has been malaria. My expertise in clinical trials combined with training in statistics and immunology has allowed me to mediate between these disciplines, identify open research questions and put data and research findings into context. I have designed and conducted clinical trials to assess vaccines and antimicrobial drugs and followed up on these trials with more fundamental studies to understand immune response and pathophysiology. I am particularly interested in controlled human infection (CHIM) studies and have set up several types of CHIM models since 2011. This work is made possible by a multinational, highly specialised team. We perform experimental human malaria infection by mosquito bite or direct inoculation of sporozoites, experimental passive immunisations using monoclonal antibodies, infection of mosquitoes from humans following transmission-blocking interventions, and vaccine studies using various platforms. Our current work is aimed at improving and expanding the portfolio of infection models, translating findings for populations in need, optimising clinical study designs and integrating complex immunology into clinical trials. Within the Radboudumc, I coordinate a group of scientists and clinicians who perform diverse challenge models, including LPS, S. pneumoniae and B. pertussis. I am committed to open science, team science and a global approach to research and health. For further detail visit OCRID (https://orcid.org/0000-0001-9101-2768).
Key Publications:
Benjamin Mordmüller (0000-0001-9101-2768) - ORCID
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