Organisation: GSK Vaccines
Biography
Dr Christoph Blohmke has many years of experience working in the enteric challenge model programme at the Oxford Vaccine Group. With a focus on data science he leads several projects interrogating Typhoid and Paratyphoid disease pathogenesis and responses to vaccination, correlates of protection, and diagnostic biomarkers. In his current role, he is leading a project aiming to develop data driven advanced analytics solutions for pre-clinical and clinical vaccines R&D.
Key Publications
Blohmke et al. Diagnostic host gene signature for distinguishing enteric fever from other febrile diseases. EMBO Mol Med. 2019 Oct;11
Gibani et al. Investigation of the role of typhoid toxin in acute typhoid fever in a human challenge model. Nat Med. 2019 Jul;25(7)
Napolitani et al. Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses. Nat Immunol. 2018 Jul;19(7)
Darton et al. Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array. Front Microbiol. 2017 Sep 19;8:1794
Jin et al. Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial. Lancet. 2017 Dec 2;390(10111):2472-2480
Blohmke et al. Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. J Exp Med. 2016 May 30;213(6):1061-77
Darton, Blohmke et al. Design, recruitment, and microbiological considerations in human challenge studies. Lancet Infect Dis. 2015 Jul;15(7):840-51