I am currently working as clinical trial supervisor at the Leiden Center for Infectious Diseases, LUMC, Leiden, in the group of Prof. Meta Roestenberg. Here I am involved in a wide scope of trials, both vaccine phase I and II studies without challenge and the controlled human infection studies conducted at the center.
During my PhD research, I set up the controlled human hookworm infection model in Leiden and conducted several studies with this model, and have worked on other CHI-models, such as malaria, schistosomiasis and non-toxicogenic Clostridium difficile.
My other research interest is in investigating ethical aspects of controlled human infection studies and investigating participant motivation, decision-making process and perception on ethical aspects of controlled human infection. I am leading several projects surveying participants on their experiences and opinions, and am interested in further collaborations.
Institution
Leiden University Medical Center
Publications
Hoogerwerf MA, Janse JJ, Kuiper VP, van Schuijlenburg R, Kruize YC, et al. Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trial. Lancet Microbe. 2023 Dec;4(12):e1024-e1034
Hoogerwerf MA, de Vries M, Roestenberg M. Money-oriented risk-takers or deliberate decision-makers: a cross-sectional survey study of participants in controlled human infection trials. BMJ Open. 2020 Jul 26;10(7):e033796
Roestenberg M, Hoogerwerf MA, Ferreira DM, Mordmuller B, Yazdanbakhsh M Experimental infection of human volunteers. Lancet Inf Dis 2018 Oct;18(10):e312-e322