Institute: KEMRI-Wellcome Trust Research Programme
Biography
My work centres around understanding naturally acquired immunity to especially malaria for vaccine design and evaluation. This underpins my main interests in understanding immunological aspects of malaria transmission with the aim of identifying, developing, and testing the efficacy of vaccine candidate antigens. I am particularly interested also in developing and/or establishing tools and model systems to identify, characterise, understand and evaluate vaccines, particularly the controlled human infection models, in disease endemic populations.
I have been able to set up the falciparum malaria human challenge model in Kilifi, Kenya to primarily unravel the course of malaria infections in the context of naturally acquired immunity and thus help identify key immune-protective targets for vaccine development. Other interests are in characterising immune-prevalence for enteric disease, particularly Shigella, with the aim of informing clinical trial evaluation of vaccine targets.
Key Publications
A list of publications can be found here.
Web Links of Interest