Institute: University of Delhi
Biography
My main focus is to work on projects such as multitarget drug discovery, multi-epitope subunit vaccine development and drug re-purposing. We have developed vaccines for human infectious diseases, e.g. COVID-19. Now working in the direction of expression of hypothetical protein i.e. multi-epitope vaccine. Also, I am working on the toxin-antitoxin loci of human pathogen and understanding their role in persister cell formation and biofilm formation.
Key Publications
- Gupta N, Behera DK, Prajapati VK, Verma VK. A comprehensive approach to discover Toxin-Antitoxin systems from human pathogen Helicobacter pylori: A poison and its antidote encapsulated in the genome. Life Sciences. 2022 Jan 1;288:120149 (IF: 6.78)
- Sharma A, Sagar K, Chauhan NK, Venkataraman B, Gupta N, Gosain TP, Bhalla N, Singh R, Gupta A. HigB1 Toxin in Mycobacterium tuberculosis Is Upregulated During Stress and Required to Establish Infection in Guinea Pigs. Front Microbiol. 2021 Nov 30;12:748890 (IF: 6.06)
- Prusty D, Gupta N, Upadhyay A, Dar A, Naik B, Kumar N, Prajapati VK. Asymptomatic malaria infection prevailing risks for human health and malaria elimination. Infect Genet Evol. 2021 Jun 30:104987 (IF: 4.39)
- Naik B, Mattaparthi VSK, Gupta N, Ojha R, Das P, Singh S, Prajapati VK, Prusty D. Chemical system biology approach to identify multi-targeting FDA inhibitors for treating COVID-19 and associated health complications. J Biomol Struct Dyn. 2021 Jun 1:1-25 (IF: 5.23)
- Naik B, Gupta N, Ojha R, Singh S, Prajapati VK, Prusty D. High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment. Int J Biol Macromol. 2020 Oct 1;160:1-17 (IF: 8.02)
- Ojha R, Gupta N*, Naik B, Singh S, Verma VK, Prusty D, Prajapati VK. High throughput and comprehensive approach to develop multiepitope vaccine against minacious COVID-19. Eur J Pharm Sci. 2020 Aug 1;151:105375 (IF: 5.11) *Equally Contributed first author
- Gupta N, Regar H, Verma VK, Prusty D, Mishra A, Prajapati VK. Receptor-ligand based molecular interaction to discover adjuvant for immune cell TLRs to develop next-generation vaccine. Int J Biol Macromol. 2020 Jun 1;152:535-545 (IF: 8.02)
- Gupta N, Khatoon N, Mishra A, Verma VK, Prajapati VK. Structural vaccinology approach to investigate the virulent and secretory proteins of Bacillus anthracis for devising anthrax next-generation vaccine. J Biomol Struct Dyn. 2020 Oct;38(16):4895-4905 (IF: 5.23)
Web Links of Interest
https://scholar.google.com/citations?user=42V34uAAAAAJ&hl=en