Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines.
A team led by Professor Andrew Steer (University of Melbourne) have published the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which they aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab.
https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30240-8/fulltext#seccestitle70