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First S pyogenes controlled human infection model published

Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines.

A team led by Professor Andrew Steer (University of Melbourne) have published the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which they aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab.

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