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DPT vaccine

Human infection (or challenge) studies involve the intentional administration of a pathogen (challenge agent) to volunteers.


The first results from the world's first SARS-CoV-2 human challenge study have been published as a pre-print. 


A Perspectives piece on how WHO recommendations were implemented to set up the world's first human challenge study with SARS-CoV-2.

S. pyogenes controlled human challenge model

Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality.


The UK will be the first country to run a Covid-19 human infection challenge study, following a favourable opinion from the UK’s clinical trials ethics body.


Typhoid fever poster

The bacterial pathogen Salmonella Typhi causes typhoid fever, which is a global health problem.

Respiratory Syncytial Virus

Professor Peter Openshaw has recorded a MOOC Vaccinology session, and describes how human challenge studies are accelerating vaccine development. 


Group A Streptococcus

Five research teams are each receiving around £100,000 of seed-funding to help set up or improve human infection studies to better understand diseases, how they spread and develop ways to prevent or treat them.

Annual Meeting 2018 audience

The 2nd HIC-Vac Annual Meeting took place on 12-13 November, 2018, in the beautiful Liverpool Medical Institute.

Guiding principles for researchers applying for funding for human infection studies could help to invigorate the field, according to a new report published by the Academy of Medical Sciences today (July 25, 2018).   

Freshwater snail

Nine research teams are each receiving around £100,000 of seed-funding to help set up or improve volunteer infection studies for a range of different diseases.

HIC-Vac stand

Over the weekend of 28-29 April, Imperial College opened its gates to welcome children and their families to the Imperial Festival.

Investing in research

The HIC-Vac Network has received additional funding from The Industrial Strategy Challenge Fund to strengthen links between UK research and industry and accelerate vaccine development.

AMS meeting 2018

This meeting, held on 6 February 2018 and hosted by the Academy of Medical Sciences and funded by HIC-Vac, the MRC and Wellcome Trust, was a fantastic opportunity for the research community to come together and discuss the regulatory and ethical c

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