Institute: hVIVO, UK
Biography
As a Clinical Science Director at hVIVO, Brandon has a particular interest in human challenge models and has supported the development of new models at hVIVO over the past 7 years. He currently designs, leads, and analyses challenge studies using RSV, Influenza virus, SARS-CoV-2 and HRV in healthy subjects. These studies have included vaccines, monoclonals, immunomodulators, and antivirals. He has previously led the assay development for volunteer recruitment and defining clinical endpoints in human challenge studies.
With a PhD in the study of highly pathogenic avian influenza (HPAI) H5N1 virus infections in avian and mammals, Brandon also has a keen interest in animal challenge models.
Brandon has developed several collaborations with Academia and UK and European Government Agencies in the past, including with Prof Laurence Tiley (University of Cambridge), Prof Helen Sang and Prof Lonneke Vervelde (The Roslin Institute, University of Edinburgh) & Dr John McCauley (National Inst for Medical Research, Francis Crick Institute).
Key Publications
Ross CS, Sutton D, Skinner P, Mahmood S, Wynne F, Londt B, Fuller CM, Mayers J, Nunez A, Hicks DJ, Brookes SM, Banyard AC, Brown IH. Comparative pathogenesis of two genotype VI.2 avian paramyxovirus type-1 viruses (APMV-1) in pheasants, partridges and chickens. Avian Pathol. 2023 Feb;52(1):36-50. doi: 10.1080/03079457.2022.2133680. Epub 2022 Nov 7.
Killingley B, Mann AJ, Kalinova M, Boyers A, Goonawardane N, Zhou J, Lindsell K, Hare SS, Brown J, Frise R, Smith E, Hopkins C, Noulin N, Löndt B, Wilkinson T, Harden S, McShane H, Baillet M, Gilbert A, Jacobs M, Charman C, Mande P, Nguyen-Van-Tam JS, Semple MG, Read RC, Ferguson NM, Openshaw PJ, Rapeport G, Barclay WS, Catchpole AP, Chiu C. Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults. Nat Med. 2022 May;28(5):1031-1041. doi: 10.1038/s41591-022-01780-9. Epub 2022 Mar 31.
Everett HE, Nash B, Londt BZ, Kelly MD, Coward V, Nunez A, van Diemen PM, Brown IH, Brookes SM. Interspecies Transmission of Reassortant Swine Influenza A Virus Containing Genes from Swine Influenza A(H1N1)pdm09 and A(H1N2) Viruses. Emerg Infect Dis. 2020 Feb;26(2):273-281. doi: 10.3201/eid2602.190486.
Hicks DJ, Kelly M, Brookes SM, Londt BZ, Ortiz Pelaez A, Orlowska A, Brown IH, Spencer YI, Núñez A. Cytokine Expression at Different Stages of Influenza A(H1N1)pdm09 Virus Infection in the Porcine Lung, Using Laser Capture Microdissection. Transbound Emerg Dis. 2016 Feb;63(1):e71-9. doi: 10.1111/tbed.12232. Epub 2014 Jun 3.PMID: 24889764
Sutton DA, Allen DP, Fuller CM, Mayers J, Mollett BC, Löndt BZ, Reid SM, Mansfield KL, Brown IH. Development of an avian avulavirus 1 (AAvV-1) L-gene real-time RT-PCR assay using minor groove binding probes for application as a routine diagnostic tool. J Virol Methods. 2019 Mar;265:9-14. doi: 10.1016/j.jviromet.2018.12.001. Epub 2018 Dec 21.
Seekings AH, Slomka MJ, Russell C, Howard WA, Choudhury B, Nuñéz A, Löndt BZ, Cox W, Ceeraz V, Thorén P, Irvine RM, Manvell RJ, Banks J, Brown IH. Direct evidence of H7N7 avian influenza virus mutation from low to high virulence on a single poultry premises during an outbreak in free range chickens in the UK, 2008. Infect Genet Evol. 2018 Oct;64:13-31. doi: 10.1016/j.meegid.2018.06.005. Epub 2018 Jun 5.
Löndt, B.Z. & Alexander, D.J. Newcastle disease virus and other avian paramyxoviruses. In A laboratory manual for the isolation, identification and characterization of avian pathogens. 6th Edition. American Association of Avian Pathologists. OmniPress Inc. Chapter 37. Pp 259-268.
Fuller, C.M., Londt, B.Z., Dimitrov, K., Lewis, N., van Boheemen, S., Fouchier, R., Coven, F., Goujgoulova, G., & Brown, I.H. An epizootiological report of the re-emergence and spread of a lineage of virulent Newcastle Disease virus into Eastern Europe. Transbound Emerg Dis. 2015 Dec 15. doi: 10.1111/tbed.12455
Kuchipudi, S.V., Tellabati, M., Sebastian, S., Nelli, R.K., Baquero, B.P., Chang, P., Londt, B.Z., Jansen, C., Vervelde , L., Brookes, S.M., Brown, I.H., Stephen P. Dunham, S.P. & Chang, K-C. (2014). Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory gene response. Veterinary Research, 45:118
Londt, B. Z., Brookes, S. M., Nash, B. J., Nunez, A., Kelly, M.D., Garçon, F., Graham, S.P & Brown, I. H. (2013). Enhanced infectivity of H5N1 highly pathogenic avian influenza (HPAI) virus in pig ex vivo respiratory tract organ cultures following adaptation by in vitro passage. Virus Res ;178(2):383-91
Jansen, C.A., de Geus, E.D., van Haarlem, D.A., van de Haar, P.M., Löndt, B.Z., Graham, S.P., Göbel, T.W., van Eden, W., Brookes S.M. & Vervelde, L. (2013). Differential lung NK cell responses in avian influenza virus infected chickens correlate with pathogenicity. Nature Scientific reports 3, 2478.
Londt, B. Z., Brookes, S. M., Kelly, M.D., Nash, B. J., & Brown, I. H. (2012). Failure to infect pigs co-housed with ducks or chickens infected experimentally with A/turkey/Turkey/1/2005 (H5N1) highly pathogenic avian influenza virus. Vet Micro. Mar 23;162(2-4):944-8
Londt, B. Z., Brookes, S. M., Nash, B. J., Nunez, A., Stagg, D. A. & Brown, I. H. (2012). The infectivity of pandemic 2009 H1N1 and avian influenza viruses for pigs: an assessment by ex vivo respiratory tract organ culture. Influenza Other Respi Viruses.
Alexander, D.J., Manvell, R.J., Irvine, R., Londt, B.Z., Cox, B., Ceeraz, V., Banks, J. and Brown, I.H. (2010) Overview of incursions of Asian H5N1 subtype highly pathogenic avian influenza virus into Great Britain, 2005-2008. Avian Dis 54, 194-200.
Breed, A.C., Harris, K., Hesterberg, U., Gould, G., Londt, B.Z., Brown, I.H. and Cook, A.J. (2010) Surveillance for avian influenza in wild birds in the European Union in 2007. Avian Dis 54, 399-404.
Londt, B.Z., Nunez, A., Banks, J., Alexander, D.J., Russell, C., Richard-Londt, A.C. and Brown, I.H. (2010) The effect of age on the pathogenesis of a highly pathogenic avian influenza (HPAI) H5N1 virus in Pekin ducks (Anas platyrhynchos) infected experimentally. Influenza Other Respi Viruses 4, 17-25.
Abolnik, C., Londt, B.Z., Manvell, R.J., Shell, W., Banks, J., Gerdes, G.H., Akol, G. and Brown, I.H. (2009) Characterisation of a highly pathogenic influenza A virus of subtype H5N2 isolated from ostriches in South Africa in 2004. Influenza Other Respi Viruses 3, 63-68.
Iqbal, M., Xiao, H., Baillie, G., Warry, A., Essen, S.C., Londt, B., Brookes, S.M., Brown, I.H. and McCauley, J.W. (2009) Within-host variation of avian influenza viruses. Philos Trans R Soc Lond B Biol Sci 364, 2739-2747.
Londt, B.Z., Nunez, A., Banks, J., Nili, H., Johnson, L.K. and Alexander, D.J. (2008) Pathogenesis of highly pathogenic avian influenza A/turkey/Turkey/1/2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally. Avian Pathol 37, 619-27.
Manvell, R.J., Londt, B.Z., Ceeraz, V., Cox, W.J., Essen, S., Banks, J., Slomka, M.J., Pavlidis, T., Irvine, R.M., Wilesmith, J.W., Sharpe, C.E., Hurst, A., Alexander, D.J. and Brown, I.H. (2008) Low pathogenic avian influenza in domestic fowl in Norfolk, England, March and April, 2006. Vet Rec 162, 278-280.
Ducatez, M.F., Tarnagda, Z., Tahita, M.C., Sow, A., de Landtsheer, S., Londt, B.Z., Brown, I.H., Osterhaus, D.M., Fouchier, R.A., Ouedraogo, J.B. and Muller, C.P. (2007) Genetic characterization of HPAI (H5N1) viruses from poultry and wild vultures, Burkina Faso. Emerg Infect Dis 13, 611-613.
Londt, B.Z., Banks, J. and Alexander, D.J. (2007) Highly pathogenic avian influenza viruses with low virulence for chickens in in vivo tests. Avian Pathol 36, 347-350.
Londt, B.Z., Banks, J., Gardner, R., Cox, W.J. and Brown, I.H. (2007) Induced increase in virulence of low virulence highly pathogenic avian influenza by serial intracerebral passage in chickens. Avian Dis 51, 396-400.
Howard, W., Hayman, A., Lackenby, A., Whitelel, A., Londt, B., Banks, J., Mccauley, J. and Barclay, W. (2007) Development of a Reverse Genetics System Enabling the Rescue of Recombinant Avian Influenza Virus A/Turkey/England/50-92/91 (H5N1). Avian Dis 51, 393-395.
Irvine, R.M., Banks, J., Londt, B.Z., Lister, S.A., Manvell, R.J., Outtrim, L., Russell, C., Cox, W.J., Ceeraz, V., Shell, W., Landeg, F.J., Wilesmith, J.W., Alexander, D.J. and Brown, I.H. (2007) Outbreak of highly pathogenic avian influenza caused by Asian lineage H5N1 virus in turkeys in Great Britain in January 2007. Vet Rec 161, 100-101.
Palmai, N., Erdelyi, K., Balint, A., Marton, L., Dan, A., Deim, Z., Ursu, K., Londt, B.Z., Brown, I.A.N.H. and Glavits, R. (2007) Pathobiology of Highly Pathogenic Avian Influenza Virus (H5N1) Infection in Mute Swans (Cygnus Olor). Avian Pathol 36, (3) 245-249.
Slomka, M.J., Coward, V.J., Banks, J., Londt, B.Z., Brown, I.H., Voermans, J., Koch, G., Handberg, K.J., Jorgensen, P.H., Cherbonnel-Pansart, M., Jestin, V., Cattoli, G., Capua, I., Ejdersund, A., Thoren, P. and Czifra, G. (2007) Identification of sensitive and specific avian influenza polymerase chain reaction methods through blind ring trials organized in the European Union. Avian Dis 51, 227-34.
Brown, I.H., Banks, J., Manvell, R.J., Essen, S.C., Shell, W., Slomka, M., Londt, B. and Alexander, D.J. (2006) Recent epidemiology and ecology of influenza A viruses in avian species in Europe and the Middle East. Dev Biol (Basel) 124, 45-50.
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