Institute: Bill and Melinda Gates Foundation
Biography
As a clinician scientist, familiar with conducting research in academic and industrial settings, my career has followed parallel paths in scientific research and clinical medicine. My main research objective has been to understand the immunological basis of protection against invasive bacterial disease with a view to prevention and treatment, focusing on communities in resource-limited settings and patients with impaired immunity. Training to consultant level as a clinical immunologist, with specialist interests in infection and immunodeficiency, has complemented this research. Extensive experience teaching basic and clinical immunology to medical student has been balanced with the successful supervision of graduate research students from the UK, Europe and Africa. I have led clinical research projects, programmes and teams in low-income settings in Africa, as well as in the UK and mainland Europe. From 2010 to 2014, I headed the research programme of a global health vaccines institute in Italy, prior to returning to the UK.
I lead projects on Salmonella and gonorrhoea vaccines and immunology, involving collaboration with African partners. Most recently, I have taken a role at the Bill and Melinda Gates Foundation where I have responsibilities for leading strategy on the development of bacterial vaccines against enteric and diarrheal diseases. At the University of Birmingham, I am the Director for the recently-established BactiVac bacterial vaccines network, a MRC-sponsored Global Challenges Research Fund Network for Vaccine Research and Development. My research has provided new insights into mechanisms of immune defence. This work has led to the development of six vaccines against invasive bacterial diseases and contributed to the establishment of a new vaccine platform.
Key Publications
A list of publications can be found here.
Web Links of Interest
http://www.jenner.ac.uk/jenner-researchers/researcher/calman-maclennan
http://www.birmingham.ac.uk/research/activity/immunology-immunotherapy/research/bactivac/index.aspx