Programme
Monday 12 November 2018
14.30-15.15 Registration, coffee/tea
15.15-15.30 Welcome from leadership
15.30-16.00 Professor Daniela Ferreira: The wonders of human infection challenge with pneumococcus.
16.00-16.30 Professor Andrew Pollard: An overview of enteric diseases and challenge models (title TBC).
16:30-16.45 Break
16:45-17.45 Keynote speaker, David Taylor-Robinson: A historical perspective of human challenge studies.
18:00-19.30 Meeting reception: drinks and canapés – The Crypt Hall
Tuesday 13 November 2018
09.15-10.55 Pump-priming award speakers, session 1
09.15-09.35 Dr Thushan De Silva: MRC Unit, The Gambia: Exploring mucosal molecular signatures associated with successful challenge with live attenuated influenza viruses.
09.35-09.55 Dr Ryan Thwaites: Imperial College London: Functional Characterisation of Mucosal Antibodies against Influenza (MUC-AB)
09.55-10.15 Dr Charles Sande: KEMRI-Wellcome Trust Research Programme, Kenya: RESpiratory Proteomics In afRican and European subjects (RESPIRE).
10.15-10.35 Dr Chris Chiu: Imperial College London, UK: Human challenge with H3N2 influenza: an optimisation pilot study promoting collaboration.
10.35-10.55 Dr Roma Chilengi: Centre for Infectious Disease Research Zambia (CIDRZ), Zambia: Development of a live attenuated rotavirus vaccine as a human infection challenge model.
10.55-11.30 Tea/coffee break
11.30-12.50 Pump-priming award speakers, session 2
11.30-11.50 Dr Giorgio Napolitani: University of Oxford, UK: Development of a platform to investigate the antigen specificity of CD4 T cell responses to respiratory pathogens.
11.50-12.10 Dr Jennifer Hill: University of Oxford, UK: “Antibody-mediated innate effector responses in human challenge models.”
12.10-12.30 Moses Egesa: MRC/UVRI Uganda Research Unit, Uganda: Preparing for Schistosoma mansoni Controlled Human Infection Studies in Uganda.
12.30-12.50 Dr Masuzyo Chirwa: Centre for Infectious Disease Research Zambia (CIDRZ), Zambia: Characterisation of host immune responses to Salmonella Typhi in an endemic setting – a comparison of natural typhoid infection with controlled human infection.
12.50-14.00 Lunch
14.00-14.30 Adrian Wildfire, SGS Life Sciences: The commercial manufacture of challenge agents.
14.30-15.00 Dr Simon Kolstoe, University of Portsmouth: Ethical frameworks for human challenge studies.
15.00-15.30 Anastazia Older Aguilar (BMGF): The international funding landscape for challenge studies.
15.30-15.45 Dr Gabriela Gomes, Liverpool School of Tropical Medicine: Why to adopt dose-response experimental designs in vaccine studies.
15.45-16.00 Reflections and questions.
16.00 Meeting closes